Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
GLPG4716 + midazolam
- Development stage
- Phase 1
- Lead developer
- Galapagos
- Modality
- Small Molecules
- Administration
- Oral, Intravenous, Intranasal, Buccal, Intramuscular
01
Overview
GLPG4716 + midazolam is a combination of **GLPG4716** (also known as OATD-01), a small molecule inhibitor of chitinase enzymes, and **midazolam**, a short-acting benzodiazepine sedative. GLPG4716 targets **chitotriosidase** and **acidic mammalian chitinase** (CHIT1/AMCase), and is under development mainly for treatment of idiopathic pulmonary fibrosis and other fibrotic diseases. Midazolam is an established benzodiazepine acting as a positive allosteric modulator of the **GABA-A receptor**, used for sedation, anesthesia, anticonvulsant therapy, and muscle relaxation. The combination is being investigated primarily in clinical pharmacology studies for potential drug-drug interactions, particularly the impact of GLPG4716 on the pharmacokinetics of midazolam, with relevance to cytochrome P450 3A4 modulation[1][2][6][7].
- Brand names
- VersedBuccolamBusulfex
- Other names
- midazolam
02
Targets
CHIA (Acidic mammalian chitinase)CHIT1 (Chitotriosidase)GABRA1 (Gamma-aminobutyric acid type A receptor alpha 1 subunit)
Beyond the preview
Go deeper on GLPG4716 + midazolam.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on GLPG4716 + midazolam.