Drug intelligence / Profile preview

GLQ223 + zidovudine

Development stage
Discontinued
Modality
Small Molecules
Administration
Oral
01

Overview

GLQ223 + zidovudine is a **combination therapy** explored for the treatment of HIV infection. **Zidovudine** (also known as azidothymidine or AZT) is a nucleoside analog reverse-transcriptase inhibitor (NRTI) that works by inhibiting the enzyme reverse transcriptase, thereby blocking HIV replication[3]. **GLQ223** is an experimental immunomodulatory agent investigated in the early 1990s as part of HIV combination regimens; preclinical data suggested it could potentially enhance immune responses but its exact molecular mechanism remains poorly defined in peer-reviewed literature. Combination regimens like GLQ223 + zidovudine were studied to evaluate their impact on immune function, viral load, and tolerability compared to zidovudine alone.

Other names
azidothymidine + GLQ223
02

Targets

Human immunodeficiency virus type 1 reverse transcriptase80S ribosome (Ribosome and ribosomal components)

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