glucagon + insulin aspart

Glucagon and insulin aspart represent a therapeutic combination used in diabetes management. Insulin aspart is a fast-acting insulin analog that helps control blood glucose levels by promoting glucose absorption from the bloodstream. It has a single amino acid substitution at position B28 where proline is replaced with aspartic acid, which decreases its propensity to form hexamers and gives it a higher rate of absorption following subcutaneous administration compared to native insulin. Glucagon works in opposition to insulin, raising blood glucose levels when they fall too low. This combination is particularly important for managing hypoglycemia (low blood sugar) that can occur with insulin therapy. Patients using insulin aspart are often advised to have glucagon available as an emergency treatment for severe hypoglycemic episodes.