Drug intelligence / Profile preview

glucagon + oxymetazoline

Development stage
Unknown
Lead developer
Eli Lilly
Modality
Small Molecules, Peptides
Administration
Intranasal
01

Overview

**glucagon + oxymetazoline** is a theoretical combination drug comprising **glucagon** and **oxymetazoline**. Glucagon is a peptide hormone used as an emergency treatment for severe hypoglycemia; it increases blood glucose by stimulating hepatic glucose production via activation of the glucagon receptor. Oxymetazoline is a small molecule alpha-adrenergic agonist used as a topical nasal decongestant and vasoconstrictor; it acts on alpha-1A, alpha-2A, alpha-2B, and other adrenergic receptors to cause vasoconstriction and reduce symptoms of nasal congestion, facial erythema, and ptosis[1][2]. No known marketed or clinically investigated product combines these two substances as a single drug; there are no identified clinical indications or manufacturers for this combination.

02

Targets

ADRA1A (α1A)ADRA1B (α1B)ADRA1D (α1D)ADRA2A (α2A)ADRA2B (α2B)ADRA2C (α2C)GCGR (Glucagon receptor)

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