glucomannan + d-chiro-inositol + cinnamomum zeylanicum + inulin

This is a multi-ingredient dietary supplement composed of glucomannan, D-chiro-inositol, Cinnamomum zeylanicum (Ceylon cinnamon) extract, and inulin. The combination is designed to target metabolic syndrome and its associated risk factors such as insulin resistance, dyslipidemia, hypertension, and abdominal obesity. - **Glucomannan** is a soluble fiber that can delay gastric emptying and reduce the absorption of cholesterol and glucose. - **D-chiro-inositol** acts as an insulin sensitizer by modulating insulin signaling pathways (notably PKCε-PI3K/AKT), reducing hepatic gluconeogenesis and improving glycemic control[7]. - **Cinnamomum zeylanicum** contains bioactive compounds like trans-cinnamaldehyde with anti-diabetic effects; it may inhibit protein tyrosine phosphatase 1B (PTP1B), enhancing insulin sensitivity[8]. - **Inulin** is a prebiotic fiber that improves gut microbiota composition, enhances satiety, reduces serum lipids, improves glycemic control, and supports weight management[6][5]. Clinical studies have shown this supplement can significantly reduce body weight/BMI, serum insulin levels/HOMA index (insulin resistance marker), total cholesterol/triglycerides/LDL cholesterol levels in patients with metabolic syndrome or type 2 diabetes when used alongside standard therapy such as metformin[1][2][3][6].

Brand names

Gludia