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glutamine + transforming growth factor-beta 2
- Development stage
- Unknown
- Lead developer
- Nestlé
- Modality
- Peptides, Small Molecules
- Administration
- Oral
01
Overview
Glutamine + transforming growth factor-beta 2 is an oral nutritional combination developed by Nestlé Health Science (Société des Produits Nestlé) for the prevention of chemotherapy-induced toxicities, particularly gastrointestinal side effects like diarrhea and mucositis in patients with digestive cancers. The formulation leverages the synergistic effects of L-glutamine, which serves as a primary energy source for enterocytes and supports intestinal mucosal integrity, and Transforming Growth Factor-beta 2 (TGF-beta 2), a potent anti-inflammatory cytokine that regulates epithelial cell proliferation and suppresses the production of pro-inflammatory mediators. By maintaining the gut barrier and modulating the local immune response, the formula aims to reduce the severity of mucosal damage caused by cytotoxic agents such as 5-fluorouracil and irinotecan.
- Other names
- TGF-beta 2-enriched nutritional formulaTGF-beta2-enriched nutritional formulaTGF-beta-2-enriched nutritional formulaGlutamine-enriched TGF-beta 2 formulaTGF-beta 2-enriched polymeric dietTGF-beta2-enriched polymeric dietTGF-beta-2-enriched polymeric dietTPD
02
Targets
TGFBR2 (TGF-β receptor type 2)TGFBR1
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