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Gold cation (1+)

Development stage
Unknown
Modality
DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules
Administration
Oral, Intramuscular
01

Overview

Gold cation (1+) is the monovalent ionic form of gold, often found as the active species within various gold compounds used therapeutically. These compounds, historically referred to as "gold salts" (though many are not true salts), have been employed in medicine for their anti-inflammatory, immunomodulatory, and antiproliferative properties. Their mechanism of action primarily involves the interaction of the gold(I) ion with biological molecules, particularly those containing thiol groups, leading to the modulation of enzyme activity and cellular processes. Historically, gold compounds were a cornerstone of chrysotherapy for rheumatoid arthritis, and current research explores their potential in oncology and as antimicrobial agents.

Other names
Gold(1+)GOLD IONGold ion(1+)Gold (Au1+)Au+
02

Targets

TXNRD2 (Thioredoxin reductase 2)

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