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Gold cation (1+) is the monovalent ionic form of gold, often found as the active species within various gold compounds used therapeutically. These compounds, historically referred to as "gold salts" (though many are not true salts), have been employed in medicine for their anti-inflammatory, immunomodulatory, and antiproliferative properties. Their mechanism of action primarily involves the interaction of the gold(I) ion with biological molecules, particularly those containing thiol groups, leading to the modulation of enzyme activity and cellular processes. Historically, gold compounds were a cornerstone of chrysotherapy for rheumatoid arthritis, and current research explores their potential in oncology and as antimicrobial agents.
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