gonadotropin-releasing hormone agonist + indocyanine green

Gonadotropin-releasing hormone agonist + indocyanine green is a combination drug product comprised of a gonadotropin-releasing hormone (GnRH) agonist and the fluorescent dye indocyanine green. GnRH agonists act primarily by stimulating the pituitary gland to release luteinizing hormone and follicle-stimulating hormone, leading to an initial surge in sex hormone production, followed by receptor downregulation and suppression of gonadotropin secretion. This ultimately lowers sex hormone levels such as estrogen and testosterone. Indications for GnRH agonists include prostate cancer, endometriosis, uterine fibroids, precocious puberty, and as a tool in assisted reproductive technology[1][2][3][4][5][6]. Indocyanine green is a water-soluble, tricarbocyanine dye used diagnostically for fluorescence imaging during surgical procedures and in cardiac, hepatic, and ophthalmic diagnostics; it fluoresces when exposed to near-infrared light, allowing for visualization of vascular and lymphatic structures. There is no evidence of a widely approved clinical formulation combining GnRH agonists with indocyanine green, suggesting this combination is investigational or used in highly specific research or surgical contexts.