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gonadotropins + dhea

Development stage: Preclinical
Modality: Small Molecules
Administration: Injection, Oral, Transdermal

Overview

The combination of gonadotropins and dehydroepiandrosterone (DHEA) is used as an adjuvant therapy in assisted reproductive technology (ART), particularly for women with diminished ovarian reserve. Gonadotropins, such as follicle-stimulating hormone (FSH) and luteinizing hormone (LH), stimulate ovarian folliculogenesis, while DHEA acts as a precursor to sex hormones that may improve oocyte yield and quality. This combination has been shown to increase antral follicle count, improve cycle outcomes, and support clinical pregnancy in poor responders[1][7]. The mechanism involves stimulation of ovarian follicles by gonadotropins and enhancement of follicular development through the conversion of DHEA into testosterone and estrogens within the ovary[1][2].

Other names: gonadotropins and DHEAgonadotropins plus dehydroepiandrosterone

Targets

CYP17A1 (Steroid 17-alpha-hydroxylase/C17,20 lyase)LHCGR (Luteinizing hormone/choriogonadotropin receptor)STS (Steroid sulfatase)HSD17B2 (17β-HSD2 / HSD17B2)ESR1 (ERα)FSHR (Follicle-stimulating hormone receptor)SULT (Sulfotransferase family 2A member 1)ESR2 (ERβ)AR (Adrenergic receptors)3β-HSD (3β-Hydroxysteroid Dehydrogenase/Δ5-4 isomerase type 1)

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