Drug intelligence / Profile preview

gonal-f + menopur

Development stage
Unknown
Lead developer
Merck KGaA
Modality
Recombinant Proteins and Enzymes
Administration
Subcutaneous
01

Overview

Gonal-f + Menopur is a combination regimen used in assisted reproductive technology (ART), particularly in ovarian stimulation protocols for in vitro fertilization (IVF) and related fertility treatments. This combination involves two injectable gonadotropin medications: - **Gonal-f** contains follitropin alfa, a recombinant form of follicle-stimulating hormone (FSH). FSH stimulates the growth and maturation of ovarian follicles by mimicking the natural action of endogenous FSH produced by the pituitary gland[8][2][4]. - **Menopur** contains menotropins (human menopausal gonadotropin or HMG), which provide both FSH and luteinizing hormone (LH) activity. The LH component supports further follicular development and oocyte maturation[3][2][7]. The combined use of these drugs aims to optimize ovarian response by providing both steady FSH stimulation from Gonal-f and additional LH activity from Menopur. This approach is tailored to individual patient needs based on their baseline hormone levels and clinical profile. Both drugs are administered via subcutaneous injection, often mixed together into a single injection for convenience when prescribed together[1][6]. The primary indication is controlled ovarian hyperstimulation as part of ART cycles such as IVF.

Brand names
Follistim + MenopurGonal-F + Menopur
Other names
follitropin alfa + menotropinsrecombinant FSH + HMGGonal-f plus Menopur
02

Targets

FSHR (Follicle-stimulating hormone receptor)LHCGR (Luteinizing hormone/choriogonadotropin receptor)

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