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gp140 + aluminum phosphate
- Development stage
- Unknown
- Lead developer
- Johnson & Johnson
- Modality
- Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes
- Administration
- Intramuscular
01
Overview
gp140 + aluminum phosphate is a combination vaccine component consisting of the recombinant HIV-1 envelope glycoprotein gp140 formulated with **aluminum phosphate** as an adjuvant. Gp140 is a stabilized form of the HIV-1 envelope protein, designed to elicit immune responses against HIV. Aluminum phosphate serves as an immunologic adjuvant to enhance the magnitude and durability of the immune response, particularly promoting antibody (Th2-type) responses to the protein antigen. This formulation has been studied as part of heterologous prime-boost regimens for the prevention of HIV-1 infection, often in combination with other vaccine components such as adenovirus-vectored vaccines. It does not have a single developer-associated brand name, but the formulation has been researched and trialed primarily by** Janssen Vaccines & Prevention B.V.**
- Other names
- Clade C gp140 + aluminum phosphateMosaic gp140 + aluminum phosphate
02
Targets
gp140 (HIV-1 gp140)gp41 (Human immunodeficiency virus type 1 glycoprotein 41)
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