Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
GPC1-ADC(MMAE)
- Development stage
- Preclinical
- Lead developer
- Kochi University
- Modality
- Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
GPC1-ADC(MMAE) is an antibody-drug conjugate (ADC) consisting of a monoclonal antibody targeting glypican-1 (GPC1) conjugated to the microtubule-disrupting agent monomethyl auristatin E (MMAE). GPC1 is a cell-surface proteoglycan overexpressed in pancreatic ductal adenocarcinoma (PDAC) on both tumor cells and cancer-associated fibroblasts (CAFs). The ADC is designed to dual-target the tumor and its stroma. Upon binding to GPC1, the ADC is internalized; in CAFs, the released MMAE can be exported via MDR-1 to induce apoptosis in neighboring cancer cells, a mechanism that helps overcome the dense stroma characteristic of PDAC. It has shown robust preclinical efficacy in patient-derived xenograft (PDX) models.
- Other names
- GPC1-ADCGPC-1-ADCGPC 1-ADC
02
Targets
GPC1 (Glypican-1)TUBB (Tubulin (alpha and beta subunits))
Beyond the preview
Go deeper on GPC1-ADC(MMAE).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on GPC1-ADC(MMAE).