gramicidin + polymyxin b sulfate + neomycin

Gramicidin + polymyxin b sulfate + neomycin is a prescription triple-antibiotic ophthalmic anti-infective formulated as a sterile eye-drop solution for topical treatment of susceptible superficial bacterial infections of the external eye and its adnexa, including conjunctivitis, keratitis, keratoconjunctivitis, blepharitis, and blepharoconjunctivitis. The combination contains gramicidin, polymyxin B sulfate, and neomycin sulfate; polymyxin B and gramicidin disrupt bacterial cell membrane permeability, while neomycin, an aminoglycoside, inhibits bacterial protein synthesis by binding the bacterial ribosome. It has been marketed under brands including Neosporin Ophthalmic and has been associated in the provided context with Bausch & Lomb as developer and manufacturer. It is a small-molecule anti-infective combination administered ophthalmically and is not approved for patients younger than 18 years according to the provided context.

Brand names

Neosporin OphthalmicNeocidinAK-SporeNeocin PGNeopticOcu-Spore-G

Other names

neomycin + polymyxin b sulfate + gramicidinneomycin and polymyxin b sulfates and gramicidin ophthalmic solutiongramicidin + polymyxin b sulfate + neomycin