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gramicidin s + cetylpyridinium chloride
- Development stage
- Unknown
- Modality
- Peptides, Small Molecules
- Administration
- Topical, Oral (local, E.g., Mouthwash, Lozenge, Spray)
01
Overview
**Gramicidin S + cetylpyridinium chloride** is a combination of two antimicrobial agents used primarily for topical antiseptic and oral/oropharyngeal disinfection purposes. **Gramicidin S** is a cyclic peptide antibiotic that disrupts bacterial cell membranes, exhibiting potent activity against gram-positive bacteria. **Cetylpyridinium chloride (CPC)** is a cationic quaternary ammonium compound with broad-spectrum antimicrobial activity, acting as an antiseptic by disrupting the cell membranes of bacteria, fungi, and some enveloped viruses, leading to rapid killing of gram-positive bacteria and moderate fungicidal effect[1][2][3][5]. This combination is used in mouth rinses, lozenges, and similar preparations for reducing oral and respiratory tract pathogens, plaque, gingivitis, and for prophylaxis/treatment of oropharyngeal infections.
- Brand names
- Grammidin Neo
- Other names
- Граммидин нео
02
Targets
MQO (Malate-quinone oxidoreductase (parasite mitochondria))Cyt-bd (Cytochrome bd quinol oxidase)NDH-2 (Type II NADH-quinone oxidoreductase)
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