gramicidin s + cetylpyridinium chloride + oxybuprocaine

**Gramicidin s + cetylpyridinium chloride + oxybuprocaine** is a topical combination drug formulated for **symptomatic and antimicrobial treatment of acute inflammatory and infectious conditions of the oropharynx**, such as pharyngitis and tonsillitis. - **Gramicidin S** is a **cyclic peptide antibiotic** with broad-spectrum bactericidal activity, particularly effective against gram-positive organisms. It disrupts bacterial cell membrane integrity, leading to cell lysis. - **Cetylpyridinium chloride (CPC)** is a **quaternary ammonium compound antiseptic** that provides rapid bactericidal and fungicidal action, especially on gram-positive bacteria and yeasts. It works by disrupting microbial membranes through its cationic surfactant properties, also offering substantivity (retention and continued activity in the mouth)[1][2][3][5][6]. - **Oxybuprocaine** is a **local anesthetic** (an ester class compound), providing fast, reversible analgesia at the site of application by blocking voltage-gated sodium channels on sensory neurons, interfering with pain signal transmission. The combination is used for short-term relief of pain, inflammation, and microbial burden during acute pharyngeal inflammatory processes. It is most commonly administered as **lozenges or sprays** for oropharyngeal topical use.

Brand names

Grammidin with anesthetic

Other names

Grammidin with anesthetic spray