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green apple + menthol + nicotine
- Development stage
- Unknown
- Lead developer
- Yale University
- Modality
- Small Molecules
- Administration
- Intravenous, Inhalation
01
Overview
This experimental combination consists of inhaled green apple and menthol e-cigarette flavors paired with intravenously administered nicotine. Developed by researchers at Yale University, it is used in clinical trials to investigate how specific flavor profiles influence the reinforcing and addictive properties of nicotine in young adult smokers. The study utilizes a double-blind, crossover design to measure drug effects via questionnaires, focusing on the interaction between sensory flavor cues and the pharmacological activation of nicotinic acetylcholine receptors in the brain's reward system. This research is part of tobacco regulatory science aimed at informing policies regarding flavored tobacco and e-cigarette products.
- Other names
- green apple + menthol-Yale University-nicotine dependencegreen apple and menthol flavor with IV nicotinegreen apple + menthol e-liquid with intravenous nicotine
02
Targets
Nicotinic Acetylcholine Receptor
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