Drug intelligence / Profile preview

green tea extract + milk thistle extract

Development stage
Unknown
Lead developer
Richard Whelan
Modality
Small Molecules
Administration
Oral
01

Overview

This combination therapy consists of oral green tea extract and milk thistle extract, evaluated as a perioperative intervention for patients undergoing colorectal cancer resection. The primary active constituents are epigallocatechin-3-gallate (EGCG) from green tea and silibinin (silymarin) from milk thistle. These natural polyphenolic compounds are hypothesized to inhibit tumor growth, cell proliferation, and the survival of cancer stem cells during the critical period surrounding surgery when the risk of recurrence is high due to surgical stress and the shedding of tumor cells. The study, led by Richard L. Whelan, focuses on the safety and potential benefit of these supplements in preventing post-surgical recurrence by offsetting the stimulatory effects of surgical injury on residual tumor cells.

Brand names
ToxiclinGreen Tea Curucmin+Milk thistle+Vitamin D3 with K2
Other names
Green Tea and Milk Thistle SupplementsEGCG + silymarinepigallocatechin-3-gallate + silibininPerioperative Green Tea and Milk Thistle
02

Targets

15-LOX (Lysyl Oxidase)COX

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