Drug intelligence / Profile preview

griseofulvin + selenium sulfide + ciclopirox + ketoconazole + baby shampoo

Development stage
Unknown
Lead developer
pharmaceutical companies
Modality
Small Molecules
Administration
Oral, Topical
01

Overview

This is a combination treatment regimen for tinea capitis (scalp ringworm) that includes oral griseofulvin and topical antifungal shampoos. The regimen consists of oral griseofulvin for systemic treatment, combined with one of several antifungal shampoos (selenium sulfide, ketoconazole, or ciclopirox) or baby shampoo as a control. This combination approach aims to eradicate the fungal infection more quickly than oral therapy alone. Griseofulvin works by inhibiting fungal cell division, while the topical antifungal shampoos help reduce fungal spores on the scalp surface. This combination has been studied in clinical trials to determine which antifungal shampoo most effectively reduces time to cure and prevents recurrence when used alongside oral griseofulvin.

02

Targets

TUBB (Tubulin (alpha and beta subunits))CYP51A1 (Sterol 14α-demethylase)

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