Drug intelligence / Profile preview

group a streptococcus vaccine (alum)

Development stage
Unknown
Lead developer
GSK
Modality
Peptides, Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

**Group A streptococcus vaccine (alum)** is GSK's investigational four-component, peptide-based vaccine formulation for prevention of infection caused by *Streptococcus pyogenes* (group A streptococcus). The formulation contains four vaccine antigen components with aluminum hydroxide (alum) adjuvant and is designed to induce protective adaptive immune responses, including antibodies directed against Strep A antigens. It is being evaluated as one of two adjuvanted formulations in a first-in-human, randomized, placebo-controlled Phase 1 study in healthy adults aged 18–25 years, using low, medium, and high intramuscular dose levels. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07085702))

Other names
4-component Group A Streptococcus pyogenes vaccine with alum4-component Strep A vaccine with alumGSK 4-component vaccine against Group A Streptococcus pyogenes with alumGSK4-component vaccine against Group A Streptococcus pyogenes with alumGSK-4-component vaccine against Group A Streptococcus pyogenes with alumStrep A alum vaccine
02

Targets

SLO (Streptolysin O)SpyCEP (Streptococcus pyogenes cell envelope protease)AdvA (Adhesion and cell division protein A)GAC (Group A carbohydrate antigen)

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