Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
growth hormone + calcitriol
- Development stage
- Unknown
- Lead developer
- National Center for Research Resources
- Modality
- Recombinant Proteins and Enzymes, Small Molecules
- Administration
- Subcutaneous, Oral
01
Overview
This combination therapy consists of recombinant human growth hormone (rhGH) and calcitriol, the active form of vitamin D3. It was investigated in a Phase II clinical trial sponsored by the National Center for Research Resources (NCRR) for the treatment of renal osteodystrophy in children and adolescents with end-stage renal disease (ESRD) on dialysis. Recombinant human growth hormone acts as an agonist at the growth hormone receptor, stimulating linear growth and bone formation, which is often impaired in pediatric renal failure. Calcitriol targets the vitamin D receptor to regulate calcium and phosphorus metabolism and suppress parathyroid hormone (PTH) secretion, addressing secondary hyperparathyroidism. The study aimed to evaluate whether the anabolic effects of growth hormone could improve bone health outcomes and counteract adynamic bone disease in this specific patient population.
- Other names
- recombinant human growth hormone + calcitriolrhGH + calcitriol
02
Targets
GHR (Growth hormone receptor)VDR (Vitamin D receptor)
Beyond the preview
Go deeper on growth hormone + calcitriol.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on growth hormone + calcitriol.