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GSK3052230 + carboplatin + paclitaxel
- Development stage
- Unknown
- Lead developer
- GSK
- Modality
- Small Molecules, Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes
- Administration
- Intravenous
01
Overview
GSK3052230 + carboplatin + paclitaxel is a combination therapy consisting of a FGF ligand trap (GSK3052230) with standard chemotherapy agents (carboplatin and paclitaxel). GSK3052230 is a soluble fusion protein consisting of the extracellular domain of human FGFR1c linked to the Fc portion of human IgG1, which acts as a ligand trap for fibroblast growth factors (FGFs). This combination was studied for the treatment of FGFR1 gene-amplified metastatic squamous non-small cell lung cancer. The mechanism involves sequestering FGFs to block their ability to activate FGF receptors, while avoiding toxicities associated with small molecule FGFR inhibitors.
- Other names
- FP-1039 + paclitaxel + carboplatinGSK3052230 (FP-1039) + paclitaxel + carboplatin
02
Targets
FGF2FGFs (Canonical Fibroblast Growth Factor ligands)
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