Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
GSK961081 + fluticasone propionate
- Development stage
- Unknown
- Lead developer
- GSK
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, PROTACs (E3 ligase recruitment) → Targeted Protein Degraders (TPDs) → Small Molecules, Bivalent/Multivalent Binders → Multivalent & Scaffold-Based Small Molecules → Small Molecules
- Administration
- Inhalation
01
Overview
GSK961081 + fluticasone propionate is an investigational fixed-dose combination therapy intended for inhalation, primarily studied for the treatment of respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). GSK961081 is a bi-functional molecule that acts as both a muscarinic receptor antagonist and a β2-adrenoreceptor agonist, providing bronchodilation. Fluticasone propionate is a synthetic glucocorticoid with potent anti-inflammatory activity, acting mainly through activation of the glucocorticoid receptor. The combination aims to provide both bronchodilation and anti-inflammatory effects in airway diseases[1][5]. The blend formulation has been shown to increase systemic exposure to fluticasone propionate compared to concurrent administration via separate inhalers[5].
- Other names
- FP (for fluticasone propionate)GSK961081/FP blend formulation
02
Targets
CHRM2 (M2)CHRM3 (M3)GR (Glucocorticoid receptor)ADRB2 (β2)
Beyond the preview
Go deeper on GSK961081 + fluticasone propionate.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on GSK961081 + fluticasone propionate.