Guanosine-2',3'-cyclophosphorothioate

Guanosine-2',3'-cyclophosphorothioate is a synthetic cyclic guanosine monophosphorothioate, a nucleotide analogue where a sulfur atom replaces one of the oxygen atoms in the phosphate group, and the phosphate forms a cyclic linkage between the 2' and 3' hydroxyls of the ribose sugar. This phosphorothioate modification typically confers resistance to enzymatic degradation by phosphodiesterases. While specific therapeutic applications for this exact compound are not widely documented, it is primarily used as a laboratory reagent for biochemical research. Related cyclic guanosine monophosphorothioate analogues (often 3',5'-cyclic forms) are known to modulate cGMP signaling pathways, for instance, by inhibiting protein kinase G (PKG).

Other names

Guanosine-2', 3'-cyclic monophosphorothioate, endo / Rp-isomer, sodium saltRp-2',3'-cGMPS