guanosine-2',3'-O-ethylidenephosphonate

Guanosine‐2',3'‐O‐ethylidenephosphonate is a synthetic small molecule analog of guanosine in which the ribose moiety is protected at the 2' and 3' positions by an ethylidene group and a phosphonate group replaces the natural phosphate linkage. It acts as an inhibitor of purine nucleoside phosphorylase (PNP), an enzyme involved in purine metabolism. This compound has been studied primarily as a biochemical probe or experimental tool for investigating PNP function and nucleotide metabolism but has not advanced to clinical development or approval for any therapeutic indication[1][2][7].

Other names

(((2R,3aR,4R,6R,6aR)-4-(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)-6-(hydroxymethyl)-tetrahydro-2H-furo(3,4-d)(1,3)dioxol-2-yl)methyl)phosphonic acid{[(2R,3aR,4R,6R,6aR)-4-(2-amino-6-oxo–6,9-dihydro–3H-purin–9–yl)–6-(hydroxymethyl)–tetrahydro–2H-furo[3,4-d][1,3]dioxol–2‑yl]methyl}phosphonic acid((2R,4R,6R,6AS)-4-(2-AMINO‑6-OXO‑1.6-DIHYDROPURIN‑9-YL)‑ ̶ ̶ ̶ -TETRAHYDROFURO[3.4-D][1.3]DIOXOL‑ ̶ YL)METHYLPHOSPHONIC ACID