Drug intelligence / Profile preview

guizhilongmu prescription + shudipingchan prescription

Development stage
Unknown
Lead developer
Henan University of Chinese Medicine
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

guizhilongmu prescription + shudipingchan prescription is a combination of two Traditional Chinese Medicine (TCM) formulas used for the treatment of Parkinson's disease. The first component, Gui Zhi Jia Long Gu Mu Li Tang (guizhilongmu prescription), is a classic formula originating from the *Shanghan Lun* (Treatise on Febrile Diseases) that is traditionally used to harmonize the 'Ying' and 'Wei' levels, stabilize the spirit, and treat symptoms such as palpitations, insomnia, and irritability. The second component, Shudi Pingchan Tang (shudipingchan prescription), is a modern TCM formula specifically designed to nourish the liver and kidney 'Yin' and extinguish internal 'wind' to alleviate tremors and rigidity. Clinical research, particularly in China, has investigated this combination for its potential to improve both motor symptoms (tremor, bradykinesia) and non-motor symptoms (sleep disturbances, anxiety) in Parkinson's patients, likely through neuroprotective mechanisms and modulation of the dopaminergic system.

Other names
Gui Zhi Jia Long Gu Mu Li Tang + Shudi Pingchan Tang桂枝加龙骨牡蛎汤 + 舒地平颤汤
02

Targets

DRD (Dopamine receptors)

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