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Ha's Bushen Huatan decoction
- Development stage
- Unknown
- Lead developer
- First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
- Administration
- Oral
01
Overview
Ha's Bushen Huatan decoction is a Traditional Chinese Medicine (TCM) herbal formula originating from the Ha family lineage of gynecologists at The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine. It is specifically indicated for the treatment of polycystic ovary syndrome (PCOS) characterized by the phlegm-dampness TCM pattern. The decoction is designed to address the dual pathology of kidney deficiency and phlegm accumulation. Clinical research, including Phase 0 trials, has focused on its ability to regulate menstrual cycles and endocrine parameters (such as testosterone and LH levels), while also investigating its impact on the gut microbiome and miRNA expression as potential mechanisms of action.
- Other names
- Huashi Bushen Huatan decoctionHa Shi Bushen Huatan decoctionHuashi decoction for tonifying kidney and huatanHa's Kidney-Tonifying and Phlegm-Resolving Decoction
02
Targets
STAT3 (Signal Transducer and Activator of Transcription 3)JUN (Transcription factor Jun)PIK3CA (Phosphoinositide 3-kinase alpha)PIK3R1 (Phosphoinositide-3-kinase regulatory subunit 1)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)TP53 (Cellular Tumor Antigen p53 R175H)
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