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Drug intelligence / Profile preview
Haemophilus b conjugate vaccine (meningococcal protein conjugate)
- Development stage
- Approved
- Lead developer
- Merck
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
PedvaxHIB is a vaccine indicated for the prevention of invasive disease caused by *Haemophilus influenzae* type b in infants and children 2 to 71 months of age. It consists of a highly purified capsular polysaccharide (polyribosylribitol phosphate, PRP) from *Haemophilus influenzae* type b covalently bound to an outer membrane protein complex (OMPC) derived from *Neisseria meningitidis* serogroup B. This conjugation converts the T-independent PRP antigen into a T-dependent antigen, resulting in enhanced antibody response and immunologic memory. The vaccine stimulates the immune system to produce Hib capsule-specific antibodies that destroy the bacterial capsule, making the organism susceptible to immune clearance. Developed and manufactured by Merck Sharp & Dohme Corp., PedvaxHIB is administered intramuscularly as part of routine childhood immunization schedules.
- Brand names
- PedvaxHIBLiquid PedvaxHIB
- Other names
- Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate)
02
Targets
PRNP (Cellular Prion Protein)OmpC (Outer membrane porin C)
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