Hb3 F(ab')2

Hb3 F(ab')2 is a divalent antibody fragment derived from the Hb3 sheep monoclonal antibody, specifically developed for the treatment of envenomation by the European adder (*Vipera berus*). It is produced by the enzymatic digestion of whole IgG molecules obtained from sheep immunized with *Vipera berus* venom, followed by affinity purification. The F(ab')2 fragment contains two antigen-binding sites but lacks the Fc region, which reduces the risk of certain adverse immune reactions while maintaining a higher molecular weight than monovalent Fab fragments. This increased size results in a longer half-life in the systemic circulation, potentially offering better protection against the delayed absorption or recurrence of venom toxins. Its primary mechanism is the high-affinity binding and neutralization of venom components, including phospholipase A2 and other toxic proteins.

Other names

Sheep anti-Vipera berus F(ab')2Hb3 antibody fragmentHb-3 antibody fragmentHb 3 antibody fragment