Drug intelligence / Profile preview

HBsAg + AS37

Development stage: Unknown
Lead developer: GSK
Modality: Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
Administration: Intramuscular

Overview

HBsAg + AS37 is a combination investigational vaccine formulation comprising **hepatitis B surface antigen (HBsAg)** and the experimental **AS37 adjuvant system** developed by GSK. HBsAg is a recombinant protein used as the antigenic component in hepatitis B vaccines, designed to elicit a protective immune response against hepatitis B virus infection. AS37 is a novel adjuvant system under investigation to enhance the immune response to the HBsAg antigen, potentially distinguishing its profile compared to other adjuvants like aluminum salt-based or AS04/AS03 systems. The vaccine is in early-stage clinical trials for safety and immunogenicity assessment in healthy adults aged 18-45 years for the prevention of hepatitis B[1].

Other names: hepatitis B surface antigen vaccine adjuvanted with AS37GSK's HBsAg vaccine adjuvanted with AS37

Targets

TLR7 (Toll-like receptor 7)

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