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hematopoietic stem cells + insulin-secreting cells
- Development stage
- Unknown
- Modality
- iPSCs → Pluripotent Stem Cells → Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous, Intra-arterial
01
Overview
This combination therapy involves the co-infusion of bone marrow-derived hematopoietic stem cells (HSC) and insulin-secreting cells (ISC) trans-differentiated from autologous adipose tissue-derived mesenchymal stem cells (AD-MSC). The approach is designed to treat insulin-dependent diabetes mellitus (IDDM) by leveraging the immunomodulatory properties of HSCs to address autoimmunity while providing a functional source of insulin-producing cells derived from the patient's own fat tissue. The therapy is typically administered under non-myeloablative conditioning to facilitate cell engraftment and has shown potential in clinical case studies for improving glycemic control and reducing exogenous insulin requirements.
- Other names
- HSC + ISChematopoietic stem cells + induced stem cellsBM-HSC + AD-MSC derived insulin-secreting cells
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