Drug intelligence / Profile preview

heparin + aspirin

Development stage
Unknown
Lead developer
Guangdong Provincial People's Hospital
Modality
Small Molecules
Administration
Intravenous, Oral
01

Overview

This therapeutic regimen consists of the sequential administration of heparin and aspirin, evaluated by Guangdong Provincial People's Hospital for postoperative management in infants and neonates undergoing surgical repair for total anomalous pulmonary venous connection (TAPVC). The protocol involves a continuous infusion of heparin starting six hours postoperatively to maintain an activated coagulation time (ACT) of 160-180 seconds, followed by oral aspirin (5 mg/kg every eight hours) for three months after the removal of deep vein catheters. The primary goal of this anticoagulation strategy is to reduce the incidence of pulmonary venous obstruction (PVO), a major and often fatal complication following TAPVC repair.

Brand names
Cal-heparinJuspirin
Other names
Anticoagulant managementAnticoagulation MedicineAnticoagulant Solutions
02

Targets

F10 (Factor Xa)PGHS-1 (Prostaglandin G/H Synthase 1)ATIII (Antithrombin III)F2 (Thrombin)

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