heparin + deoxycholic acid

A combination drug consisting of **heparin**, a highly sulfated glycosaminoglycan with potent anticoagulant properties, and **deoxycholic acid**, a bile acid used here as a conjugating agent to enhance oral bioavailability. The conjugate exhibits **amphiphilic properties** allowing it to be absorbed via the intestine when administered orally, bypassing the need for parenteral injection. This conjugate retains high anticoagulant activity (anti-FXa) and demonstrates antiangiogenic effects, attributed in part to size-controlled inhibition of growth factors such as VEGF. The primary therapeutic rationale is improved oral delivery of heparin for thromboprophylaxis (DVT, PE) and for antitumor applications due to antiangiogenic and cytostatic properties, as demonstrated in preclinical studies.

Other names

heparin-deoxycholic acid conjugateheparin-DOCA conjugateLMWH-DOCAHDHFD