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hepatitis b vaccine (National Cancer Institute)
- Development stage
- Unknown
- Lead developer
- Merck
- Modality
- Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes
- Administration
- Intramuscular
01
Overview
The hepatitis b vaccine is a recombinant subunit vaccine designed to provide active immunity against infection caused by all known subtypes of the hepatitis B virus (HBV). In the specific context of the National Cancer Institute (NCI) Phase II clinical trial (NCT02863926), it is utilized as a clinical probe to evaluate the efficacy of Glyco-Recombinant Human Interleukin-7 (CYT107) in restoring immune competence in older adults (aged 60 and over) who have recently completed chemotherapy for breast, colon, or bladder cancer. These patients often experience chemotherapy-induced immunosuppression and immunosenescence, which can lead to suboptimal responses to standard vaccinations. The vaccine works by presenting the hepatitis B surface antigen (HBsAg) to the immune system, thereby stimulating the production of protective antibodies.
- Other names
- Hepatitis B virus vaccineHepB vaccineHBV vaccine
02
Targets
HBsAg (Hepatitis B surface antigen)
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