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Drug intelligence / Profile preview
hepatitis B vaccine (recombinant) (Merck & Co., c2b9e6)
- Development stage
- Phase 3
- Lead developer
- Merck
- Modality
- Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes
- Administration
- Intramuscular
01
Overview
H-B-VAX II (also known as HBVaxII or Recombivax HB) is a recombinant hepatitis B vaccine developed and manufactured by Merck Sharp & Dohme (MSD). It is designed to prevent hepatitis B virus (HBV) infection across all age groups, including newborns, infants, children, adolescents, and adults. The vaccine contains purified recombinant hepatitis B surface antigen (HBsAg) produced in yeast (*Saccharomyces cerevisiae*) cells, which is adsorbed onto an amorphous aluminum hydroxyphosphate sulfate adjuvant. Upon intramuscular administration, the HBsAg stimulates the immune system to produce protective anti-HBs antibodies, conferring active immunity against all known subtypes of the hepatitis B virus.
- Brand names
- H-B-VAX IIHBVaxIIRecombivax HBHBVaxPro
- Other names
- hepatitis B vaccinerecombinant hepatitis B surface antigenHBsAg vaccinehepatitis B surface antigen (recombinant)
02
Targets
HBsAg antigenic loop
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