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hepatitis B vaccine (Tongji Hospital)
- Development stage
- Unknown
- Lead developer
- Tongji Hospital
- Modality
- Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes
- Administration
- Intramuscular
01
Overview
Hepatitis B vaccine (60 ug) is a high-dose recombinant therapeutic vaccine used to stimulate immune responses in patients with chronic hepatitis B. In the Endeavor Study conducted at Tongji Hospital, this vaccine is utilized as part of a combination therapy regimen alongside interferon alfa-2b and interleukin-2. The treatment is specifically evaluated in entecavir-experienced patients who have achieved HBeAg seroclearance, with the goal of inducing HBsAg loss and achieving a functional cure. The 60 ug dosage is significantly higher than standard prophylactic doses, intended to overcome immune tolerance in chronic carriers by stimulating HBsAg-specific T-cell and B-cell responses.
- Other names
- therapeutic hepatitis B vaccineHepatitis B Vaccine (60ug)
02
Targets
HBsAg (Hepatitis B surface antigen)
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