Heptex (Natural Wellness)

Heptex is a herbal medicinal product developed by Natural Wellness, consisting of a standardized combination of powdered extracts from the aerial parts of *Phyllanthus niruri* (Dukung Anak) and the fruits of *Silybum marianum* (Milk Thistle). It is primarily indicated for the treatment of nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD). The drug exerts its effects through antioxidant, anti-inflammatory, and hepatoprotective mechanisms, including the inhibition of lipid peroxidation and the modulation of inflammatory cytokines such as TNF-alpha. Clinical evaluation in a Phase II trial (NCT05343780) demonstrated that Heptex is safe and well-tolerated, showing significant reductions in liver enzymes like ALT and AST in patients at risk for NASH.

Brand names

Heptex

Other names

Phyllanthus niruri and Silybum marianum combinationDukung Anak and Milk Thistle combination