Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
HIFU + ThermoDox
- Development stage
- Unknown
- Lead developer
- IMUNON
- Modality
- Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Small Molecules
- Administration
- Intravenous
01
Overview
ThermoDox combined with MRI-guided High Intensity Focused Ultrasound (MR-HIFU) is an investigational combination therapy developed by Imunon (formerly Celsion Corporation) for the treatment of painful bone metastases. ThermoDox is a heat-activated liposomal formulation of doxorubicin (lyso-thermosensitive liposomal doxorubicin). The system utilizes MR-HIFU to provide precise, non-invasive heating (39.5-42°C) of targeted bone lesions, which triggers the rapid release of high concentrations of doxorubicin directly at the tumor site. This approach aims to provide effective pain palliation while minimizing systemic toxicity for patients with bone metastases from breast, lung, or prostate cancer who have failed or are ineligible for radiation therapy.
- Brand names
- ThermoDox
- Other names
- MR-HIFU + ThermoDoxMRI-guided High Intensity Focused Ultrasound + ThermoDox
02
Targets
TOP2A (DNA topoisomerase II)DNA
Beyond the preview
Go deeper on HIFU + ThermoDox.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on HIFU + ThermoDox.