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high molecular weight hyaluronic acid + low molecular weight hyaluronic acid
- Development stage
- Unknown
- Lead developer
- InSpec Solutions
- Modality
- Implantable Hydrogels → Hydrogel Systems → Drug Delivery Systems, Non-biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Injectable Hydrogels → Hydrogel Systems → Drug Delivery Systems
- Administration
- Topical, Intraarticular, Ophthalmic
01
Overview
**High molecular weight hyaluronic acid + low molecular weight hyaluronic acid** is a combination formulation of hyaluronic acid polymers differentiated by size. This product leverages the distinct properties of each molecular weight for synergistic benefit. High molecular weight hyaluronic acid (HMW-HA) typically forms a surface film, providing immediate hydration, plumping effects, and a moisture barrier, but exhibits limited skin penetration. Low molecular weight hyaluronic acid (LMW-HA) penetrates deeper into the skin layers, promoting longer-lasting hydration and potentially stimulating healing processes. Used topically in skin care, this multiscale formulation aims to deliver both instant surface hydration and lasting moisturization throughout epi- and dermal layers. In medical contexts, hyaluronic acid of varying molecular weights is used for intra-articular injection in osteoarthritis and wound healing, with HMW-HA showing evidence for pain relief and improved function. The mechanism of action is primarily through water retention, tissue hydration, barrier reinforcement, and modulation of cell behavior in skin and joints.
- Other names
- high molecular weight hyaluronic acid + low molecular weight hyaluronic acid
02
Targets
STAB2 (Stabilin-2)CD44 (CD44 antigen)LYVE1 (Lymphatic vessel endothelial hyaluronic acid receptor 1)
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