histamine + mannitol + sodium chloride

Histamine + mannitol + sodium chloride is a diagnostic combination used in provocation tests to evaluate airway and nasal hyperreactivity. Developed by Diater Laboratorio, this product is primarily utilized in the diagnosis and assessment of allergic rhinitis, allergic conjunctivitis, and controlled allergic asthma. The active component, histamine (administered as histamine dihydrochloride), acts as a potent agonist at histamine H1 receptors, inducing localized physiological responses such as bronchoconstriction, increased vascular permeability, and glandular secretion. These responses are measured to determine the threshold of sensitivity in patients. Mannitol is included in the lyophilized formulation as a stabilizing excipient, while 0.9% saline (sodium chloride) serves as the isotonic diluent for reconstitution and administration. This combination is a standardized tool for clinical allergy diagnostics rather than a therapeutic intervention.

Brand names

Histamina Diater

Other names

Histamine Nasal Provocation TestHistamine Bronchial Provocation TestHistamine Nasal ChallengeHistamine Bronchial Challenge