Drug intelligence / Profile preview

HLX07 + HLX10 + mFOLFOX6

Development stage
Unknown
Lead developer
Henlius
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration
Intravenous
01

Overview

**HLX07 + HLX10 + mFOLFOX6** is an experimental combination regimen comprising three components: HLX07, HLX10, and mFOLFOX6. - **HLX07** is a recombinant, humanized monoclonal antibody that targets epidermal growth factor receptor (EGFR), functioning as an EGFR inhibitor—similar in mechanism to cetuximab. - **HLX10** is a recombinant, humanized anti-programmed cell death protein 1 (PD-1) monoclonal antibody, functioning as a PD-1 immune checkpoint inhibitor—similar in mechanism to pembrolizumab or nivolumab. - **mFOLFOX6** is a well-established chemotherapy regimen including oxaliplatin (platinum-based cytotoxic), fluorouracil (antimetabolite), and leucovorin (folinic acid, a biomodulator). This combination is under development primarily for cancer indications, leveraging direct cytotoxicity (from mFOLFOX6) along with dual targeted immunotherapies (HLX07, HLX10).

02

Targets

EGFR T790M (Epidermal growth factor receptor T790M mutant)TS (Thymidylate synthase)PDCD1 (Programmed cell death protein 1 receptor)DNA

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