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HLX07 + serplulimab
- Development stage
- Phase 2
- Lead developer
- Henlius
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
HLX07 + serplulimab is a combination therapy consisting of two monoclonal antibodies. HLX07 is a recombinant, humanized anti-EGFR antibody developed to target the epidermal growth factor receptor (EGFR), thereby inhibiting tumor cell proliferation and survival. Serplulimab is an anti-PD-1 antibody that blocks the interaction between PD-1 and its ligands PD-L1/PD-L2, enhancing T-cell mediated immune responses against tumors. This combination has been investigated primarily for advanced or metastatic esophageal squamous cell carcinoma (ESCC), where it has shown promising antitumor activity and manageable toxicity in phase 2 clinical trials[1][4][5][8]. The regimen may also include chemotherapy agents such as cisplatin and 5-fluorouracil in some studies.
- Brand names
- HANSIZHUANG
- Other names
- HLX07 + HLX10
02
Targets
EGFR (Epidermal growth factor receptor)PDCD1 (Programmed cell death protein 1 receptor)
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