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HMPL-453 + docetaxel
- Development stage
- Unknown
- Lead developer
- Hutchison Medipharma
- Modality
- Nucleic Acid-Directed Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral, Intravenous
01
Overview
HMPL-453 + docetaxel is a combination therapy under investigation for advanced solid tumors, comprising HMPL-453—a novel, highly selective, and potent small molecule inhibitor targeting fibroblast growth factor receptors FGFR1, FGFR2, and FGFR3—and docetaxel, a taxane-class chemotherapy. HMPL-453 inhibits the FGFR pathway, which is implicated in tumor growth, angiogenesis, and therapy resistance, while docetaxel disrupts microtubule dynamics, inhibiting cell division. This combination targets tumors with aberrant FGFR signaling and is being assessed for safety, tolerability, pharmacokinetics, and preliminary efficacy, particularly in patients with advanced solid tumors refractory to standard treatments[2][6].
- Other names
- HMPL-453HMPL453HMPL 453fanregratinib
02
Targets
FGFR2 (Keratinocyte growth factor receptor)FGFR3 (Fibroblast growth factor receptor 3)FGFR1 (Fibroblast growth factor receptor 1)TUBB (Tubulin (alpha and beta subunits))
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