Drug intelligence / Profile preview

hormone replacement therapy + etidronate

Development stage
Unknown
Lead developer
Assistance publique - Hôpitaux de Paris
Modality
Small Molecules
Administration
Oral
01

Overview

A combination therapy approach using hormone replacement therapy (HRT) and etidronate for treating bone loss in postmenopausal women. HRT replaces hormones that decline during menopause, while etidronate is a bisphosphonate that inhibits bone resorption by interfering with osteoclast activity. This combination has shown an additive effect on bone mineral density in the hip and vertebrae, particularly beneficial for women who continue to lose bone density despite conventional HRT alone.

Other names
combined therapy with estrogen and etidronateintermittent cyclical etidronate and hormone replacement therapyICT-etidronate combined with HRT
02

Targets

ER (Estrogen receptor)FDPS (Farnesyl pyrophosphate synthase)

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