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HPC,A
- Development stage
- Unknown
- Lead developer
- St. Jude Children's Research Hospital
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous
01
Overview
HPC,A (Hematopoietic Progenitor Cells, Apheresis) is a cellular therapy product utilized by St. Jude Children's Research Hospital for the treatment of high-risk hematologic malignancies, including leukemia and lymphoma. The product consists of hematopoietic stem cells collected from a haploidentical (half-matched) donor via apheresis. To optimize clinical outcomes, the cells are processed using the CliniMACS system for CD34+ selection (to enrich for progenitor cells) or CD45RA depletion (to remove naive T cells associated with graft-versus-host disease). This approach aims to achieve rapid hematopoietic engraftment and promote a graft-versus-leukemia effect, often in combination with donor-derived natural killer (NK) cells and a total lymphoid irradiation (TLI)-based conditioning regimen.
- Other names
- Hematopoietic Progenitor Cells, ApheresisHaploidentical Donor Hematopoietic Progenitor CellsCD34+ selected HPC,ACD45RA depleted HPC,A
02
Targets
TCR (T cell antigen receptor complex)CD45RA (T-cell surface glycoprotein CD45 isoform RA)
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