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HPDCs-T (The Third Affiliated Hospital of Sun Yat-sen University)
- Development stage
- Phase 2
- Lead developer
- The Third Affiliated Hospital of Sun Yat-sen University
- Modality
- Allogeneic CAR-T → CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Autologous CAR-T → CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, TCR-Engineered T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Dendritic Cell Vaccines → Immune Effector Cells → Other Cell Types → Cell Therapies, Tumor-Infiltrating Lymphocytes (TILs) → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
HPDCs-T is an autologous cell-based immunotherapy developed by the Third Affiliated Hospital of Sun Yat-Sen University for the treatment of chronic hepatitis B. The therapy involves the generation of dendritic cells (DCs) from a patient's hematopoietic progenitors, which are then pulsed (sensitized) with hepatitis B surface antigen (HBsAg) derived from an HBV vaccine. These sensitized DCs are used to activate and expand autologous T cells *ex vivo*. The resulting HBsAg-sensitized dendritic cell-activated T cells (HPDCs-T) are administered intravenously to the patient. The goal of this therapy is to restore or enhance HBV-specific immune responses to achieve HBsAg loss and viral clearance. It has been evaluated in clinical trials both as a monotherapy and in combination with standard antiviral agents such as pegylated interferon and nucleoside/nucleotide analogs.
- Other names
- HBsAg-sensitized dendritic cell-activated T cellsHBV vaccine-pulsed dendritic cell-induced T cellshematopoietic progenitor-derived T cellsHBsAg-sensitized dendritic cell-activated T cells-Third Affiliated Hospital, Sun Yat-Sen University
02
Targets
HBsAg (Hepatitis B surface antigen)
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