Drug intelligence / Profile preview

Hsc70NTD-TRP2(153-417)

Development stage: Preclinical
Modality: Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics

Overview

Hsc70NTD-TRP2(153-417) is an experimental recombinant **therapeutic cancer vaccine** fusion protein comprising the N-terminal ATPase domain of murine heat shock cognate protein 70 and amino acids 153-417 of murine tyrosinase-related protein 2, a melanoma-associated tumor-rejection antigen. In a B16 murine melanoma model, the refolded fusion protein retained ATPase activity, induced TRP2-specific cytotoxic T-lymphocyte responses, and delayed tumor growth following immunization. It is a preclinical academic construct rather than a clinically developed or marketed medicine. ([sciencedirect.com](https://www.sciencedirect.com/science/article/pii/S0165247806000848))

Other names: Hsc70NTD-TRP2 153-417Hsc-70NTD-TRP2 153-417Hsc 70NTD-TRP2 153-417Hsc70NTD-TRP2(153-417)Hsc70NTD-TRP2153-417Hsc-70NTD-TRP2153-417Hsc 70NTD-TRP2153-417

Targets

TYRP2 (Tyrosinase-related Protein 2)

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