Drug intelligence / Profile preview

huangqi + danshen

Development stage
Preclinical
Lead developer
Guangzhou University of Chinese Medicine
Administration
Oral
01

Overview

**huangqi + danshen** is a combination of two Chinese herbal medicines: *Astragalus mongholicus* (huangqi) and *Salvia miltiorrhiza* (danshen), frequently used in Traditional Chinese Medicine (TCM). This drug pair is primarily employed for cardiovascular indications, including coronary heart disease and chronic kidney disease. Mechanistically, it acts through multiple pathways: huangqi is known for replenishing "Qi" and supporting metabolic regulation, while danshen activates blood circulation and possesses blood-thinning properties. The combination exerts synergistic effects in improving cardiac function, reducing myocardial infarction size, attenuating fibrosis, regulating hyperlipidaemia, reducing blood viscosity, maintaining circulatory system homeostasis, and protecting against kidney injury. These effects are supported by preclinical network pharmacology and metabolomic analyses, indicating action on metabolic pathways such as lipid metabolism, energy metabolism, amino acid metabolism, and NAD⁺ homeostasis[2][3][4][5].

Other names
Astragalus mongholicus + Salvia miltiorrhizaHuang Qi + Dan ShenHuangqi-Danshen decoctionHDD
02

Targets

NOS3 (eNOS)ESR2 (ERβ)SCD1 (Stearoyl-CoA desaturase 1)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)EGFR T790M (Epidermal growth factor receptor T790M mutant)FOS (Activator Protein 1)

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