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Huayu Qiangshen Tongbi optimization C decoction + Shenlingbaizhu powder

Development stage
Preclinical
Lead developer
Guangdong Provincial Hospital of Traditional Chinese Medicine
Administration
Oral
01

Overview

Huayu Qiangshen Tongbi optimization C decoction + Shenlingbaizhu powder is a combination of two traditional Chinese medicine (TCM) herbal formulas. The first component, Huayu-Qiangshen-Tongbi (HQT) decoction, is a multi-herb formula developed for the treatment of rheumatoid arthritis and related inflammatory conditions. It has demonstrated anti-inflammatory and immunomodulatory effects by regulating multiple signaling pathways involved in inflammation and bone metabolism, including the Toll-like receptor pathway, PI3K–Akt pathway, hypoxia-inducible factor 1 pathway, MAPK pathway, activator protein 1 signaling pathway, and suppression of NF-κB-induced inflammation via upregulation of miR-125b[2][3][7]. The second component, Shenlingbaizhu powder (Shen Ling Bai Zhu San), is a classic TCM prescription used to strengthen the spleen and replenish Qi. It is commonly prescribed for spleen deficiency syndromes manifesting as digestive disorders such as chronic gastritis or irritable bowel syndrome; it exerts its effects through anti-inflammatory action, immunomodulation, antioxidant activity, regulation of cell signal transduction pathways (including NF-κB), and modulation of gut microbiota[6][8][9]. This combination aims to address both systemic inflammation/autoimmunity (via HQT) and gastrointestinal/spleen deficiency symptoms (via SLBZP), reflecting an integrative approach typical in TCM.

Other names
Huayu-Qiangshen-Tongbi Decoction + Shenling Baizhu SanHQT + SLBZPHuayu-Qiangshen-Tongbi formula plus Shenling Baizhu powder
02

Targets

HIF1A (Hypoxia-inducible factor 1-alpha)TLR4 (Toll-like receptor 4)NF-κBFOS (Activator Protein 1)

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