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HuHuangLianzonggan capsule (Tasly Group)
- Development stage
- Unknown
- Lead developer
- Tasly Pharmaceutical
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
HuHuangLianzonggan capsule is a botanical drug candidate developed by Tasly Pharmaceutical Group for the treatment of nonalcoholic steatohepatitis (NASH). It is a purified extract containing total glycosides from the rhizome of *Picrorhiza scrophulariiflora*, a plant used in traditional Chinese medicine. The primary active constituents are iridoid glycosides, including picroside I and picroside II. These compounds are thought to provide hepatoprotective effects by reducing oxidative stress, inhibiting pro-inflammatory pathways such as NF-κB, and potentially modulating lipid metabolism. The drug is currently undergoing Phase 2 clinical trials (HHL-HEPAR) to evaluate its safety and efficacy in patients with NASH.
- Brand names
- huhuangelianzonggan capsule
- Other names
- Huhuanglian ZongganTotal glycosides of Picrorhiza scrophulariiflora
02
Targets
SIRT1 (NAD-dependent protein deacetylase sirtuin-1)NF-κB
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