Drug intelligence / Profile preview

human papillomavirus 9-valent vaccine, recombinant (Merck & Co.)

Development stage
Unknown
Lead developer
Merck
Modality
Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

**Human papillomavirus 9-valent vaccine, recombinant** is a prophylactic recombinant vaccine marketed as Gardasil 9. It contains virus-like particles composed of the L1 major capsid protein from human papillomavirus types 6, 11, 16, 18, 31, 33, 45, 52, and 58 and induces type-specific neutralizing antibody responses. It is used to prevent HPV-associated cancers, precancerous lesions, and genital warts; it does not treat established HPV infection, cervical cancer, or other HPV-related disease. The Zimbabwe study context involves administration alongside a separate hepatitis B vaccine, but Gardasil 9 itself does not prevent hepatitis B infection or hepatitis B-associated liver cancer. ([fda.gov](https://www.fda.gov/media/90064/download))

Brand names
Gardasil 9Gardasil9Gardasil-9
Other names
9-valent human papillomavirus vaccine, recombinanthuman papillomavirus 9-valent vaccinehuman papillomavirus 9-valent vaccine, recombinantrecombinant human papillomavirus 9-valent vaccine
02

Targets

HPV58 L1 (Human papillomavirus type 58 major capsid protein L1)Human papillomavirus type 18 L1 major capsid proteinHPV11 L1HPV52 L1 (Human papillomavirus type 52 major capsid protein L1)HPV33 L1HPV6 L1 (Human papillomavirus type 6 major capsid protein L1)HPV16 (Human papillomavirus type 16)HPV31 L1HPV45 L1

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