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**Human papillomavirus 9-valent vaccine, recombinant** is a prophylactic recombinant vaccine marketed as Gardasil 9. It contains virus-like particles composed of the L1 major capsid protein from human papillomavirus types 6, 11, 16, 18, 31, 33, 45, 52, and 58 and induces type-specific neutralizing antibody responses. It is used to prevent HPV-associated cancers, precancerous lesions, and genital warts; it does not treat established HPV infection, cervical cancer, or other HPV-related disease. The Zimbabwe study context involves administration alongside a separate hepatitis B vaccine, but Gardasil 9 itself does not prevent hepatitis B infection or hepatitis B-associated liver cancer. ([fda.gov](https://www.fda.gov/media/90064/download))
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